{
  "withdrawal": {
    "subj": "017",
    "what": "withdraws consent after Period 1 (no Period 2 dose)",
    "usubjid": "SIMBE01-101-017"
  },
  "emesis": {
    "subj": "029",
    "period": 2,
    "onset_min": 45,
    "what": "vomits 45 minutes after the Period 2 dose",
    "usubjid": "SIMBE01-101-029"
  },
  "carryover": {
    "subj": "008",
    "period": 2,
    "frac": 0.025,
    "what": "measurable Period 2 pre-dose concentration at 2.5% of that period's Cmax (below the 5% rule)",
    "usubjid": "SIMBE01-101-008"
  },
  "missed": {
    "subj": "035",
    "period": 1,
    "tpt": 12,
    "what": "12 h sample in Period 1 not collected",
    "usubjid": "SIMBE01-101-035"
  },
  "late_sample": {
    "subj": "012",
    "period": 1,
    "tpt": 4,
    "dev_min": 25,
    "what": "4 h sample in Period 1 drawn 25 minutes late",
    "usubjid": "SIMBE01-101-012"
  },
  "mid_blq": {
    "subj": "024",
    "period": 2,
    "tpt": 6,
    "what": "6 h sample in Period 2 reported below the LLOQ between quantifiable samples (a simulated sample-handling problem; no reassay)",
    "usubjid": "SIMBE01-101-024"
  }
}