{
  "engine": "PKNCA 0.12.1",
  "options": {
    "auc.method": "lin up/log down",
    "conc.blq": {
      "first": "keep",
      "middle": "keep",
      "last": "keep"
    },
    "min.hl.points": 3,
    "allow.tmax.in.half.life": false
  },
  "parameter_rules": {
    "min_hl_adj_r_squared": 0.9,
    "max_aucinf_pext_pct": 20,
    "implementation": ["PKNCA exclude(): adj.r.squared below 0.9 flags get.parameter.deps(\"half.life\")", "PKNCA exclude(): aucpext.obs above 20 flags aucinf.obs"],
    "excluded_values": [
      {
        "rule": "aucpext.obs > 20",
        "profiles": 3,
        "parameters": "AUCIFO",
        "which": "SIMBE01-101-021 Period 2; SIMBE01-101-029 Period 1; SIMBE01-101-029 Period 2"
      }
    ]
  },
  "time": "ARRLT (actual time from the period's dose); pre-dose samples set to time 0",
  "profiles": 79,
  "intervals": "0 to Inf, one interval per participant and period",
  "blq": {
    "setting": {
      "first": "keep",
      "middle": "keep",
      "last": "keep"
    },
    "pknca_default": {
      "first": "keep",
      "middle": "drop",
      "last": "keep"
    },
    "profiles_with_blq_between_quantifiable": 1,
    "profiles_changed_vs_pknca_default": 1
  }
}